Zoloft can help in PMS (premenstrual syndrome), freeing you from the emotional and psychological symptoms of PMS. Zoloft, either taken alone or with other mood restoring medication, is particularly helpful for women with severe, type D PMS or PMDD (premenstrual dysphoric disorder). In fact, studies of Zoloft in more than 500 women with PMDD (premenstrual dysphoric disorder) showed an improvement in symptoms in more than 60 percent of patients. More and more doctors are now prescribing Zoloft for the treatment of PMS depression and anxiety. Ideally, the decision to take Zoloft for PMS relief should be made in consultation with both your gynecologist and a psychiatrist. Zoloft is an antidepressant, belonging to the same class of drugs (selective serotonin re-uptake inhibitors, or SSRI) as Prozac/Sarafem. Zoloft works by altering the action of the neurotransmitter serotonin. Serotonin generates calming, sedative feelings.
Zoloft blocks the body's re-absorption of serotonin, making it more available to brain cells and therefore preventing or reducing feelings of anxiety and depression during PMS. Zoloft doesn't have to be taken all month. For PMS relief, Zoloft works even if only taken during the final two weeks of the menstrual cycle (the period between ovulation and the beginning of the period). Even women who take Zoloft at the onset of their PMS symptoms get some benefit. Interestingly, while it may take 4 to 6 weeks of treatment with Zoloft or Prozac for people with other forms of depression to feel benefit, women with severe PMS or PMDD (premenstrual dysphoric disorder) can feel results almost immediately. Why this is so isn't yet known, but there's some evidence that in PMS and PMDD (premenstrual dysphoric disorder), Zoloft and other SSRIs also beneficially affect progesterone metabolism."
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